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KMID : 0614020020170010008
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Journal of Pharmaceutical Sciences (C.N.U.)
2002 Volume.17 No. 1 p.8 ~ p.15
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Determination of Stability Constant for Propranolol and β-Cyclodextrin Complex by Capillary Electrophoresis
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Lim Hwan-Mi
Choi Jong-Hyuk
Park Kyung-Lae
Kang Jong-Seong
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Abstract
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The stability constants (K_st) for the inclusion complexes between propranolol and three types of cyclodextrin (CD) such as β-CD, methyl (ME)-β-CD and hydroxypropyl (HP)-β-CD were determined by capillary electrophoresis (CE). The enantiomers of propranolol possess relatively high affinity towards ME-β-CD with stability constants of 78 and 76 M^-1 for (R)- and (S)-propranolol, respectively. The affinity of propranolol in HP-β-CD was relatively low compared with that in ME-β-CD, i.e. 39 and 36 M^-1 for (R)- and (S)-propranolol, respectively. In spite of the lower affinity, the K_R/K_S ratio of propranolol in HP-β-CD (K_R/K_S = 1.08) was higher than that in ME-β-CD (K_R/K_S = 1.03) indicating that HP-β-CD would be more efficient than ME-β-CD or β-CD in chiral separation of propranolol by CE.
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KEYWORD
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Propranolol, enantioselectivity, cyclodextrin, stability constant
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